Error 1327 Invalid Drive: Drive :\ (Some Drive Letter Other Than C:\)
Occurs when you have a registry entry in Windows pointing to the Drive letter that shows up in the error message.
We found the PersonFolder property inside the above Key was pointing to the U:\ Drive on one customers computer
This article from Microsoft may also appy if needed.
http://support.microsoft.com/default.aspx?scid=kb;en-us;327763
WARNING: Using Registry Editor incorrectly can cause serious problems that may require you to reinstall Windows. TATEMS And PChelpltd cannot guarantee that problems resulting from the incorrect use of Registry Editor can be solved. Use Registry Editor at your own risk.
Click the link below for more from Microsoft about editing registry entries
http://support.microsoft.com/kb/136393
Before you attempt to make any changes to your registry you should know what you are doing. You should also do a system backup and create a restore point in Windows before making any changes.